Table 1.
Formulation | Surfactant | Co-surfactant | Ratio | Size (nm) | PDI | EE (%) |
---|---|---|---|---|---|---|
LN 1 | Tw | – | – | 120.87±8.24 | 0.163±0.012 | 96.16±2.51 |
LN 2 | TC | – | – | 537.70±14.86 | 0.194±0.014 | 93.91±1.63 |
LN 3 | Lec | – | – | Gelation | ||
LN 4 | Lec | TC | 3:1 | 201.27±6.96 | 0.207±0.014 | 98.60±6.93 |
LN 5 | PL | TC | 3:1 | 89.51±1.39 | 0.158±0.004 | 66.14±6.56 |
LN 6 | PL | TC | 1:1 | 114.68±2.02 | 0.173±0.014 | 99.16±4.31 |
LN 7 | PL | Lec | 3:1 | 78.52±0.12 | 0.151±0.002 | 45.47±8.13 |
LN 8 | PL | Lec | 1:1 | 129.00±1.99 | 0.232±0.006 | 46.83±6.56 |
Abbreviations: PDI, polydispersity index; EE, entrapment efficiency; Tw, Tween® 80; Lec, L-α-phosphatidylcholine; TC, taurocholic acid sodium salt hydrate; PL, Pluronic® F127; w/w, weight/weight; LN, lipid nanoparticles.