Table 2.
Physical characteristics of the optimized cyclosporine A (CsA) loaded and unloaded lipid nanoparticles
| Formulation | Size (nm) | PDI | Zeta potential (mV) |
|---|---|---|---|
| LN Lec:TC-CsA | 201.27±6.96 | 0.207±0.014 | −27.8±1.5 |
| LN Lec:TC-Blank | 202.43±8.65 | 0.210±0.012 | −30.0±1.4 |
| LN PL:TC-CsA | 114.68±2.02 | 0.173±0.014 | −20.6±2.5 |
| LN PL:TC-Blank | 111.11±2.20 | 0.165±0.007 | −22.7±2.7 |
| LN Tw-CsA | 120.87±8.24 | 0.163±0.012 | −14.6±1.9 |
| LN Tw-Blank | 117.96±6.39 | 0.164±0.022 | −16.2±2.9 |
Abbreviations: PDI, polydispersity index; LN, lipid nanoparticles; PL, Pluronic® F127; Tw, Tween® 80; Lec, L-α-phosphatidylcholine; TC, taurocholic acid sodium salt hydrate.