Figure 5.

Age acceleration versus blood cell counts in HIV-uninfected control subjects (controls). The first 2 rows (A–H) and the last 2 rows (I–P) present results for controls from blood data sets 5 and 7, respectively. A and I, DNA methylation (DNAm) age versus chronological age. Age acceleration was defined as the residual resulting from the regression line (red line). Age acceleration versus natural killer (NK) cells (B and J), CD14⁺ monocytes (C and K), granulocytes (D and L), CD4⁺ T cells (E and M), CD8⁺ T cells (F and N), naive CD8⁺ T cells (G and O), and exhausted (CD28⁻CD45RA⁻) CD8⁺ T cells (H and P). The blood cell abundance measures were estimated on the basis of DNAm data (“Methods” section).