Table II.
Venom Components of Conus geographus Venom
| A. NIRVANA CABAL PEPTIDES | |||
|---|---|---|---|
| Peptide: | Gene Superfamily: | Mechanism (reference): | Amino acid sequence (mature venom peptide): |
| Conantokin-G | B1 | NMDA receptor antagonist (Mena et al. 1990; Donevan and McCabe 2000) | GEγaγLQγNQγLIRγKSN |
| σ-Conotoxin | S | 5HT3 antagonist (England et al. 1998) | GCTRTCGGOc KCTGTCTCTNSSKCGCRYNVHPSG(BrW)d GCGCACS* |
| Contulakin G | C | Neurotensin receptor agonist (Craig et al. 1999; Lee et al. 2015) | Zb SEEGGSNAT§ KKPYIL |
| Con-Ins GI | ± | Insulin receptor (Safavi-Hemami et al. 2015) |
|
| Lys-conopressin-G | ± | Vasopressin receptor (Cruz et al. 1987) |
|
| B. MOTOR CABAL PEPTIDES | |||
| μ-GIIIA | M | Voltage-gated Na channel (Nav1.4 subtype) (Cruz et al. 1985; Cruz et al. 1989) |
|
| ω-GVIA | O1 | Voltage-gated Calcium Channel (Cav 2.2 subtype) (Olivera et al. 1984) |
|
| α-GI | A | Nicotinic Acetylcholine Receptor (Adult muscle subtype) (Gray et al. 1981) |
|
Post-translational modifications:
a
γ γ-carboxyglutamate;
b
Z pyroglutamate;
T§
= O-glucosylation of Threonine with β-D-Gal-(1→3)-α-D-GalNAc-(1→) disaccharide;
c
O hydroxyproline;
d
BrW 6-bromotryptophan;
*
C-terminal amidation.
+
No superfamily assigned.