Table II.
A. NIRVANA CABAL PEPTIDES | |||
---|---|---|---|
Peptide: | Gene Superfamily: | Mechanism (reference): | Amino acid sequence (mature venom peptide): |
Conantokin-G | B1 | NMDA receptor antagonist (Mena et al. 1990; Donevan and McCabe 2000) | GEγaγLQγNQγLIRγKSN |
σ-Conotoxin | S | 5HT3 antagonist (England et al. 1998) | GCTRTCGGOc KCTGTCTCTNSSKCGCRYNVHPSG(BrW)d GCGCACS* |
Contulakin G | C | Neurotensin receptor agonist (Craig et al. 1999; Lee et al. 2015) | Zb SEEGGSNAT§ KKPYIL |
Con-Ins GI | ± | Insulin receptor (Safavi-Hemami et al. 2015) | |
Lys-conopressin-G | ± | Vasopressin receptor (Cruz et al. 1987) | |
B. MOTOR CABAL PEPTIDES | |||
μ-GIIIA | M | Voltage-gated Na channel (Nav1.4 subtype) (Cruz et al. 1985; Cruz et al. 1989) | |
ω-GVIA | O1 | Voltage-gated Calcium Channel (Cav 2.2 subtype) (Olivera et al. 1984) | |
α-GI | A | Nicotinic Acetylcholine Receptor (Adult muscle subtype) (Gray et al. 1981) |
Post-translational modifications:
γ γ-carboxyglutamate;
Z pyroglutamate;
= O-glucosylation of Threonine with β-D-Gal-(1→3)-α-D-GalNAc-(1→) disaccharide;
O hydroxyproline;
BrW 6-bromotryptophan;
C-terminal amidation.
No superfamily assigned.