Table 2.
Intention-to-treat analysis (last observed value carried forward) of 17-item Hamilton Depression rating scale (HAMD-17) scores at different time points during the trial in the two groups of patients with major depressive disorder
| time point | duloxetine group (n=146) |
paroxetine group (n=150) |
t | p | reduction from baseline | t | p | |
|---|---|---|---|---|---|---|---|---|
| duloxetine | paroxetine | |||||||
| baseline | 23.7 (3.0) | 23.8 (3.1) | 0.53 | 0.596 | — — | — — | — — | — — |
| 7 days | 21.0 (4.4) | 20.7 (5.0) | 0.43 | 0.669 | 2.7 (3.4) | 3.1 (4.3) | 0.94 | 0.349 |
| 14 days | 17.5 (5.6) | 16.2 (6.4) | 1.87 | 0.063 | 6.1 (5.3) | 7.6 (6.5) | 2.18 | 0.030 |
| 28 days | 13.3 (7.1) | 14.2 (6.4) | 1.20 | 0.233 | 9.4 (6.2) | 10.6 (7.3) | 1.43 | 0.153 |
| 42 days | 11.8 (7.5) | 11.0 (7.7) | 0.92 | 0.357 | 11.8 (7.4) | 12.8 (7.9) | 1.13 | 0.259 |
| 56 days | 10.2 (7.8) | 9.8 (8.3) | 0.45 | 0.655 | 13.5 (8.0) | 14.1 (8.3) | 0.64 | 0.523 |