Table 3.
Comparison of mean (sd) outcome measures before and after duloxetine treatment in patients with depression with (n=37) or without (n=40) a history of affective disorders in first-degree relativesa
| measure | group | baseline | 2 weeks | 4 weeks | 6 weeks | 8 weeks | 12 weeks | Ftime (p) | Fgroup (p) | Ftime*group (p) |
|---|---|---|---|---|---|---|---|---|---|---|
| HAMD-17 | with family history | 23.2 (3.7) | 14.0 (4.5) | 10.1 (3.6) | 9.3 (3.4) | 8.4 (3.3) | 7.8 (3.8) | 443.97 (<0.001) | 0.01 (0.912) | 0.01 (0.938) |
| without family history | 22.8 (3.4) | 14.2 (5.0) | 10.2 (4.1) | 9.4 (3.6) | 8.3 (3.5) | 7.6 (4.2) | ||||
| HAMA | with family history | 20.2 (5.1)a | 12.0 (4.1) | 9.8 (3.7) | 8.0 (3.9) | 6.3 (3.0) | 5.8 (2.8) | 247.04 (<0.001) | 0.74 (0.392) | 3.01 (0.087) |
| without family history | 17.2 (5.0)a | 12.3 (4.4) | 9.3 (2.9) | 8.3 (2.1) | 6.4 (2.5) | 5.5 (2.4) | ||||
| SHAPS | with family history | 38.9 (4.5)a | 31.2 (4.2) | 28.5 (3.1) | 27.9 (3.1) | 27.0 (3.1) | 26.3 (3.6) | 251.13 (<0.001) | 3.95 (0.051) | 3.31 (0.073) |
| without family history | 36.2 (5.0)a | 29.6 (3.9) | 27.5 (3.0) | 27.2 (2.8) | 26.0 (2.9) | 25.7 (3.1) | ||||
| BDI | with family history | 16.7 (5.2) | 8.5 (3.9) | 6.4 (2.3) | 6.3 (2.3) | 5.7 (2.2) | 5.4 (2.6) | 260.18 (<0.001) | 0.40 (0.530) | 0.07 (0.791) |
| without family history | 15.3 (4.4) | 8.9 (3.7) | 6.6 (2.5) | 6.0 (2.3) | 5.3 (2.1) | 4.9 (2.5) |
HAMD-17, 17-item version of the Hamilton Depression rating scale
HAMA, Hamilton Anxiety rating scale
SHAPS, Snaith-Hamilton Pleasure Scale
BDI, Beck Depression Inventory
a except for the baseline scores of HAMA (t=2.59, p=0.012) and SHAPS (t=2.55, p=0.013), there were no statistically significant differences in any of the measures at any of the 6 time periods.