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. 2015 Oct 27;6:316. doi: 10.3389/fgene.2015.00316

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Copyright © 2015 Chandler-Brown, Choi, Park, Ocampo, Chen, Le, Sutphin, Shamieh, Smith and Kaeberlein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sorbitol promotes longevity by a mechanism distinct from insulin-like signaling, sir-2.1, AMP kinase, and the hypoxic response. (A) Addition of 5% sorbitol to the NGM extends the lifespan of both daf-16(mu86) and daf-2(e1370) mutants (p < 0.001, t-test). Addition of 5% sorbitol to the NGM is also sufficient to extend lifespan in (B) sir-2.1(ok434) null animals, (C) aak-2(ok524) null animals, and (D) hif-1(ia04) null animals (p < 0.001 in each case, t-test). (E) Dietary restriction by bacterial deprivation (BD) or (F) mutation of eat-2 fails to further extend the lifespan of animals grown on NGM supplemented with 5% sorbitol (p = 0.21, t-test).