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The osmotic response pathway is associated with lifespan extension. (A) Genetic ablation of induced glycerol biosynthesis in the gpdh-1(ok1558);gpdh-2(kb33) double mutants prevents lifespan extension from 5% sorbitol. (B) Two mutations with constitutive activation of the osmotic stress response, osm-5(p813) and osm-7(n1515), are long-lived under control conditions (p < 0.001, t-test).
