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. 2015 Oct 27;5:14919. doi: 10.1038/srep14919

Figure 7. The proposed model for novel activation mechanism of Arf6 in CME.

Figure 7

Dynamin2 (Dyn2) is recruited to the neck of the forming vesicles, where it induces membrane scission to produce free endocytic vesicles upon GTP hydrolysis. At this step, Dyn2 activates Arf6 through EFA6B and/or EFA6D.