Table 2. Diagnostic value of the body fluid T-SPOT.TB, ADA and unstimulated IFN-γ based on fluid category.

	Pleurisy		Peritonitis		Meningitis
	T-SPOT.TB	ADA	IFN-γ	T-SPOT.TB	ADA	T-SPOT.TB	ADA
Number of studies (N)	9 (744)	63 (8093)	22 (2101)	3 (116)	4 (264)	5 (173)	10 (1472)
Sensitivity (95% CI)	0.94 (0.91–0.96)	0.92 (0.90–0.93)	0.89 (0.87–0.91)	0.94 (0.83–0.99)	1.00 (0.93–1.00)	0.75 (0.64–0.84)	0.79 (0.75–0.83)
Heterogeneity* (P)	11.29 (0.186)	327.03 (<0.001)	67.54 (<0.001)	0.13 (0.938)	0.0 (1.000)	9.54 (0.049)	44.80 (<0.001)
Specificity (95% CI)	0.80 (0.75–0.85)	0.90 (0.89–0.91)	0.97 (0.96–0.98)	0.87 (0.76–0.94)	0.97 (0.94–0.99)	0.91 (0.83–0.96)	0.91 (0.89–0.93)
Heterogeneity (P)	62.19 (<0.001)	303.79 (<0.001)	32.66 (0.050)	0.05 (0.977)	1.14 (0.768)	5.41 (0.248)	63.60 (<0.001)
PLR (95% CI)	4.83 (2.00–11.66)	9.03 (7.19–11.35)	23.45 (17.31–31.78)	6.93 (3.75–12.80)	26.8 (13.3–54.0)	8.02 (4.19–15.37)	6.85 (4.11–11.41)
Heterogeneity (P)	90.45 (<0.001)	380.14 (<0.001)	21.21 (0.446)	0.05 (0.973)	0.16 (0.984)	4.13 (0.389)	51.66 (<0.001)
NLR (95% CI)	0.11 (0.06–0.20)	0.10 (0.07–0.14)	0.11 (0.07–0.16)	0.07 (0.02–0.21)	0.038 (0.01–0.15)	0.29 (0.20–0.42)	0.29 (0.19–0.44)
Heterogeneity (P)	19.20 (0.014)	381.73 (<0.001)	62.36 (<0.001)	0.14 (0.931)	0.24 (0.9)	11.25 (0.024)	34.82 (<0.001)
DOR (95% CI)	46.99 (13.69–161.28)	110.08 (69.96–173.20)	272.7 (147.5–504.2)	97.86 (25.31–378.45)	–	26.46 (11.38–61.56)	26.92 (12.72–56.97)
Heterogeneity (P)	28.43 (<0.001)	291.60 (<0.001)	30.04 (0.091)	0.13 (0.938)	–	4.91 (0.297)	29.75 (<0.001)
AUC (SEM)	0.97 (0.012)	0.96 (–)	0.99 (–)	0.93 (0.161)	0.99 (0.00)	0.93 (0.045)	0.92 (–)

^*Chi-square value.

Abbreviations: AUC, area under the curve; DOR, diagnostic odds ratio; N, number of participants; NLR, negative likelihood ratio; PLR, positive likelihood ratio.