Table 4.

Logistic regression analysis of factors associated with use of high dose MTX.

Factors	Odds ratio [CI]	p-Value
Age	1.00 [0.97 to 1.04]	0.87
Female	2.22 [0.75 to 6.62]	0.15
Smoking	0.60 [0.08 to 4.71]	0.63
CD [vs UC]	4.46 [1.02 to 19.4]	<0.05
Prior surgery	1.24 [0.47 to 3.28]	0.66
IBD duration	1.00 [1.00 to 1.00]	0.90
CD
Location
Colonic	1.78 [0.28 to 11.35]	0.55
Ileocolonic	2.82 [0.58 to 13.84]	0.20
Upper GI involvement	2.83 [0.44 to 18.18]	0.10
Behavior
Stenotic	0.59 [0.15 to 2.24]	0.43
Penetrating	0.35 [0.10 to 1.24]	0.10
Perianal disease	1.01 [0.38 to 2.68]	0.98
UC
Location
Pancolitis	4 * 10^8 [0.00 to 0.00]	1.00
Severity
Moderate	0 [0 to 0]	1.00
Severe	3 [0.08 to 107.45]	0.55

[CI], confidence interval; CD, Crohn’s disease; UC, ulcerative colitis; IBD, inflammatory bowel disease; GI, gastrointestinal.

Predictors of high dose MTX. Cox and Snell R² p = 0.09; Nagelkerke R² = 0.13.