Table 3.
Function classification for genes showing expression differences in esophageal carcinoma and pericancerous epithelium that were > 2 or < 0.5 fold from the control tissue
| Gene function classification |
Carcinoma/normal |
Pericancerous/normal |
|||||
| N | > 2 | < 0.5 | N | > 2 | < 0.5 | ||
| 1 | Proto-oncogenes and tumor suppression genes | 2 | 1 | 1 | 0 | 0 | 0 |
| 2 | Cell signals and transducing proteins | 3 | 2 | 1 | 3 | 3 | 0 |
| 3 | Cell cycle proteins | 6 | 5 | 1 | 0 | 0 | 0 |
| 4 | Extra-pressure reaction proteins | 1 | 0 | 1 | 0 | 0 | 0 |
| 5 | Cell regulatory proteins | 7 | 7 | 0 | 3 | 3 | 0 |
| 6 | Cell apoptosis related proteins | 1 | 1 | 0 | 1 | 0 | 1 |
| 7 | DNA synthesis, repair and recombinant proteins | 3 | 3 | 0 | 0 | 0 | 0 |
| 8 | DNA binding, transcription and its factor | 6 | 4 | 2 | 1 | 1 | 0 |
| 9 | Cell receptors | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | Cell surface antigen and adhesion proteins | 10 | 8 | 2 | 4 | 4 | 0 |
| 11 | Ion-channel and transporters | 24 | 14 | 10 | 2 | 2 | 0 |
| 12 | Metabolism-related proteins | 21 | 10 | 11 | 6 | 4 | 2 |
| 13 | Protein synthesis-related genes | 14 | 7 | 7 | 2 | 1 | 1 |
| 14 | Development-related genes | 1 | 1 | 0 | 2 | 2 | 0 |
| 15 | Other genes | 27 | 18 | 9 | 7 | 7 | 0 |
| 16 | New genes | 9 | 4 | 5 | 0 | 0 | 0 |
| Total | 135 | 85 | 50 | 31 | 27 | 4 | |