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. 2015 Oct 27;6:307. doi: 10.3389/fphys.2015.00307

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Copyright © 2015 Luder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical, radiographic, and microscopic features of regional odontodysplasia. (A) An intraoral view of the affected mandibular right quadrant taken from a boy at the age of 2 years 8 months shows the primary second molar (arrow) which was later examined microscopically. (B) Apical radiograph of the mandibular front at the age of 4 years 7 months illustrating the ghost-like appearance of the permanent incisors. (C) A panoramic radiograph at the age of 5 years reveals a single root in the primary mandibular right second molar (arrow) as compared to the normally spread roots in the contralateral tooth. (D) Macroscopic buccal view of the single-rooted primary mandibular second molar extracted at the age of 5 years 4 months. (E,F) An overview (E) and detail (F) backscattered electron micrograph of a bucco-lingual ground section show hypoplastic enamel (e), tubular dentin containing clefts (d), interglobular dentin (igd), and amorphous masses (am) consisting of densely calcified globules and cellular dentin. (G,H) An overview (G) and detail (H) light micrograph of the cerviacl root surface stained with toluidine blue depict the root canal (rc), normal dentin (d), the granular layer of Tomes (glt), acellular cementum (ac), and Sharpey's fibers (arrow) attaching the periodontal ligament (pdl) to the root. (I) Backscattered electron micrograph of the apical root region revealing normal dentin (d), the granular layer of Tomes (glt), and cellular cementum (cc) with signs of hard tissue resorption. Original magnification (D,E) 5x, (F) 75x, (G) 50x, (H) 200x, (I) 220x.