Figure 8.

Fate progressions of germline cells. Germline cells follow an invariant developmental path from a mitotic state (red), to the pachytene stage I (orange), to diplotene (green), and finally to diakinesis (blue). This progression of fates observed in the hybrid model can be abstracted to an executable model, where we can characterize different mutations in terms of distinct fate progressions. This new executable model highlights that any instability of the germline cells in the absence of ligand can always lead to an invariant fate progression if the initial mitotic state is stable.