Figure 4.

Median per residue contribution to cooperative unfolding by sequential parsing using SEED. (A) Median per-residue m/F values for excised and in situ fragments. (B) Median cooperativity ratio, CR. (C) Cooperativity ratio difference, ΔCR. (D and E) Median CR of A1 and A3 mapped to structure. (F) Difference, ΔCR mapped to the A1 structure. (Black) Residues that do not structurally align. (A–C) Line breaks correspond to residues aligned to a gap (no structurally equivalent residue). To see this figure in color, go online.