Table 1.
Baseline characteristics of responders and non-responders based on a ≥ 5 % increase in stroke volume to a colloid fluid infusion of 250 mL
| Responders (n = 19) | Non-responders (n = 16) | P | |
|---|---|---|---|
| Age, year | 69 [55–78] | 66 [57–73] | 0.46 |
| Sex, male | 11 (58) | 10 (63) | 0.78 |
| Female | 8 (42) | 6 (37) | |
| BMI (kg/m2) | 24.7 [22.5–29] | 24.2 [20–27.3] | 0.22 |
| Premorbidity | |||
| Cardiovascular | 11 (58) | 11 (69) | 0.51 |
| Liver disease | 1 (5) | 3 (19) | 0.21 |
| Malignancy | 6 (32) | 5 (31) | 0.98 |
| Source of sepsis | |||
| Abdominal | 7 (37) | 8 (50) | 0.43 |
| Respiratory | 8 (42) | 5 (31) | 0.51 |
| Other | 4 (21) | 3 (19) | 0.86 |
| Bacteraemia | 12 (63) | 10 (63) | 0.97 |
| Time since admission (h) | 24 [5–60] | 48 [16–144] | 0.16 |
| APACHE II | 28 [20–32] | 24 [18–27] | 0.08 |
| SOFA | 11 [7–14] | 11 [8–12] | 0.81 |
| Mechanical ventilation | 19 (100) | 13 (81) | 0.05 |
| Vasopressor support | 13 (68) | 12 (75) | 0.67 |
| NE (µg kg−1 min−1) | 0.06 [0–0.3] | 0.18 [0–0.37] | 0.55 |
| Prior fluid balance (mL) | 4,838 [2,921–10,216] | 7,281 [2,725–9,537] | 0.74 |
| Survival | 9 (47) | 10 (63) | 0.37 |
Median [interquartile ranges] or number and percentage, where appropriate. BMI body mass index, APACHE II acute physiology and chronic health evaluation score, SOFA sequential organ failure assessment, NE norepinephrine