Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Chronic fatigue state induced by sleep deprivation. Accumulation of sleep deprivation caused brain dysfunction with/without biological dysfunctions. Fundamental biofunctions (biological clock, energy metabolism, autonomic activity, and immune system), sleep disorders, and brain functions interacted with each other and created negative chains. Chronic fatigue state was observed as the output of brain dysfunctions
