Figure 3. Transient plasticity in US-activated LA neurons is absent in DAT-NR1 KO mice.

(A) Average waveform of recorded units in Ctrl and KO mice that were activated by the US. (B) Baseline firing rate of individual units in Ctrl and KO mice that were activated by the US (Control: n = 32, 26, and 28 Days 1–3, respectively; DAT-NR1 KO: n = 25, 34, and 35 Days 1–3, respectively). (C) Proportion of neurons from Ctrl and KO mice that were activated or inhibited by the US. (D) Average normalized firing rate of US activated neurons in Ctrl mice across days of conditioning. (E) Average normalized firing rate of US-activated neurons in KO mice across days of conditioning. (F) Average area under the curve (AUC) of activated response for Ctrl and KO mice across days. (G–I) Comparison of activated responses of Ctrl and KO mice during day 1 (G), day 2 (H), and day 3 of conditioning (I). Data are presented as the mean ± S.E.M. Repeated measures ANOVA, p < 0.001, Bonferroni post-test.

DOI: http://dx.doi.org/10.7554/eLife.08969.006

Figure 3—figure supplement 1. US-inhibited LA neurons do not change across days of conditioning.

(A) Average normalized firing rate of US-inhibited neurons in control mice across days of conditioning (Control: n = 8, 16, and 14 Days 1–3, respectively; DAT-NR1 KO: n = 8, 8, and 9 Days 1–3, respectively). (B) Average normalized firing rate of US- inhibited neurons in DAT-NR1 KO mice across days of conditioning. (C) Average area under the curve (AUC) of inhibited response for control and DAT-NR1 KO mice across days. (D–F) Comparison of inhibited responses of control and DAT-NR1 KO mice during day 1 (D), day 2 (E), and day 3 of conditioning (F). Data are presented as the mean ± S.E.M.

DOI: http://dx.doi.org/10.7554/eLife.08969.007