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. 2015 Nov;146(5):387–398. doi: 10.1085/jgp.201511475

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© 2015 Santa Cruz et al.

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Figure 7. — Functional properties of mouse Cx40 A96S gap junctions. (A) Gap junction currents (I_j) recorded from a HeLa cell pair transfected with mCx40A96S in response to a 5-s bipolar pulse from ±10 to ±110 mV using increments of 20 mV. (B) Summary plot of normalized g_j versus V_j. The continuous black line represents the best fit of the data to the Boltzmann equation (V_j,o = 85 mV, g_j,min = 0.71, and z = 1.1; n = 6). (C) Averaged total conductance measured from human A96S (8.9 ± 1.5 nS; n = 34; pink bar) and mouse A96S (1.7 ± 0.2 nS; n = 64; pink striped bar) junctions (P < 0.001; Mann–Whitney rank-sum test). (D) Single-channel currents (I_j) recorded from a HeLa mCx40A96S cell pair maintained at V_j of 50 mV. Solid line, zero current level. The all-points current histogram (right-hand side) revealed a conductance of 149 pS. Error bars represent means ± SEM.