Table 1.
Summary of conductance and permeability data collected from mutant and WT Cx40
| hCx40WT | rCx40WT | Cx40A96S | Cx40G38D | Cx40M163V | |
| Junctional conductance (nS) | |||||
| HeLa | 8.5 ± 0.6 (n = 32) | 24.1 ± 3.5 (n = 22) | 8.9 ± 1.5 (n = 34) | 8.6 ± 0.9 (n = 51) | 9.1 ± 1.0 (n = 38) |
| N2A | 8.9 ± 1.8 (n = 18) | n.a. | 7.3 ± 2.7 (n = 10) | 8.3 ± 2.7 (n = 10) | 7.2 ± 2.1 (n = 17) |
| Unitary conductance (pS) | 135 | 125a | 139 | 220 | 131 |
| Vj,o (mV) | 48 | 48 | 49 | 52 | 48 |
| z | 3.9 | 4.1 | 2.1 | 2.1 | 3.1 |
| gj,min | 0.24 | 0.24 | 0.20 | 0.20 | 0.22 |
| LY flux (molec/channel/s) | 989 | 650 | 1,137 | 7,758 | 2,242 |
| Pγ (cm3/s) | 0.82 × 10−15 | 0.54 × 10−15 | 0.95 × 10−15 | 6.52 × 10−15 | 1.87 × 10−15 |
| LY/K+ | 0.0030 | 0.0021 | 0.0034 | 0.0145 | 0.0070 |
| EtBr flux (molec/channel/s) | 5,059 | 5,454 | 16,156 | 1,121 | 19,218 |
| Pγ (cm3/s) | 3.61 × 10−15 | 3.35 × 10−15 | 10.91 × 10−15 | 0.73 × 10−15 | 13.08 × 10−15 |
| EtBr/K+ | 0.0131 | 0.0131 | 0.0376 | 0.0016 | 0.0474 |
n.a., not applicable.