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. 2015 Nov;146(5):375–386. doi: 10.1085/jgp.201511503

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© 2015 Vij et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Partial agonists generate fewer modes than does ACh. (A; left) Example clusters for αP197A adult AChRs ([agonist] = 1 mM; −100 mV; open is down). (Right) Cluster P_O histogram for TMA with peaks at 0.04 ± 0.01 and 0.87 ± 0.10. Arrow, P_O for TMA in WT AChRs (0.30 ± 0.06). The full agonist ACh has four P_O populations (Fig. 2 B, bottom). (B) αP197A adult AChRs activated by a saturating [Cho] (100 mM; 70 mV; open is up). (Top) Two modes are apparent. (Bottom left) Interval duration histograms and example clusters of each mode. (C) Phi (slope) analysis of αP197A choline modes. The fold-change in the di-liganded gating equilibrium constant is caused mainly by a similar fold-change in the channel-opening rate constant.