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. 2015 Nov;146(5):375–386. doi: 10.1085/jgp.201511503

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© 2015 Vij et al.

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Figure 8. — Alanine scan of the aromatic core. (A) δW57A. (Top) Example currents from a single-site, αδ-only AChR (3 mM ACh; 70 mV; open is up). (Bottom) Cluster P_O and interval duration histograms. Only one P_O population is apparent (K_d^ACh given in Table 1). (B) Example currents from other alanine mutants. Multiple modes are apparent (two-site, adult AChRs; 30 µM ACh; −100 mV; open is down). αP197A was present for all.