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. 2015 Nov;146(5):343–356. doi: 10.1085/jgp.201511456

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© 2015 Cherny et al.

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Figure 4. — Saturation of ΔpH-dependent gating occurs independently of loss of proton selectivity of Trp²⁰⁷ mutants. The mean ± SEM (error bars) change in V_rev for a 1-U change in pH is plotted for WT hH_V1 (closed blue circles) and for W207X (open blue circles). The shift in V_g_H,max/10 in the same cells is also plotted for WT hH_V1 (closed red squares) and for W207X (open red squares). Numbers of cells for both parameters are one, six, eight, and five for increasing pH_o in WT; one, six, and eight for increasing pH_i in WT; one, five, 11, six, and three for increasing pH_o in W207X; and one and four for increasing pH_i in W207X. The difference in V_rev in W207X versus WT was significant at pH_o 7–8 (P < 0.02) and 8–9 (P < 0.001). The difference in V_g_H,max/10 in W207X versus WT was significant at pH_o 6–7 (P < 0.02) and 7–8 (P < 0.0001).