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. 2015 Nov;146(5):343–356. doi: 10.1085/jgp.201511456

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© 2015 Cherny et al.

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Figure 6. — Replacement of Trp²⁰⁷ decreases the Arrhenius activation energy for hH_V1 opening. The activation time constant, τ_act, was determined in one cell during families of pulses at various temperatures at symmetrical pH 7. The sequence is indicated in the inset. The Q₁₀ was somewhat higher at lower voltages (e.g., 4.3 at 20 mV and 3.7 at 100 mV, for the entire temperature range). As reported previously for native H_V1 (DeCoursey and Cherny, 1998), E_a also increased at lower temperatures. Temperature drift during families of pulses was on the order of 1°C.