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. 2015 Nov;146(5):343–356. doi: 10.1085/jgp.201511456

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© 2015 Cherny et al.

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Figure 8. — Proton selectivity is perfect in WT hH_V1 (A) but compromised in Trp²⁰⁷ mutants (B). Proton selectivity is indicated by the proximity of measured values of V_rev and the Nernst potential for H⁺, E_H. Data were obtained in whole-cell (closed symbols) and inside-out patch configuration (open symbols). In whole-cell measurements, the color-coded pH_i solution was in the pipette, and pH_o was varied, with lines connecting measurements in each cell. In inside-out patch measurements, pH_o was the pipette solution and pH_i was varied. Whole-cell measurements in B include eight W207F, 12 W207A, and one W207S cell. For W207X mutants, currents in patches were too small to allow reliable estimation of V_rev.