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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Immunol. 2015 Aug 3;195(5):2122–2133. doi: 10.4049/jimmunol.1500396

FIGURE 8.

FIGURE 8

Model for the Ca2+ dependent signaling pathway activated by PAR2. Activation of PAR2 receptors by serine proteases (trypsin) and peptide agonists (SLIGRL and SLIGKV) evokes phospholipase C (PLC) stimulation leading to IP3 production and ER store-release through the opening of IP3 receptors. Release of Ca2+ from intracellular stores leads to activation of STIM1 which opens CRAC channels comprised of Orai1 subunits. Ca2+ influx through CRAC channels activates calcineurin-NFAT signaling to transcriptionally induce IL-6 and IL-8 production, likely in conjunction with other pathways. CsA, Cyclosporin A; U73122, PLCβ inhibitor; BTP2 and RO2959, CRAC channel inhibitors.