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Network diagram of the heat-shock response model. Highlighted reactions (red or gray) are those that have explicit temperature dependences, as described by Eqs. 15, 19, and 20. (HSE, heat-shock element; HSF, heat-shock factor; HSP, heat-shock protein; MFP, misfolded protein; mRNA, heat-shock protein messenger RNA; and Prot, healthy protein.) To see this figure in color, go online.
