Figure 5.
Analysis of protein misfolding as a function of temperature and duration of exposure. (A) MFP versus time for three different temperatures. (B) AUC for 800 simulations similar to those in (A) for a variety of heating duration and temperature combinations. (Blue curve) Ratio of MFP AUC at a particular temperature to that at 43°C for the same duration. (Red curve) Ratio of MFP AUC at a particular temperature and duration to that at 43°C for the corresponding cumulative equivalent minutes at 43°C (CEM43) duration. (Shaded regions) Standard deviation over multiple different heating durations.