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. 2015 Oct 26;211(2):339–358. doi: 10.1083/jcb.201506002

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© 2015 Marchesin et al.

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Figure 8. — ARF6 expression increases during breast tumor progression. (A) ARF6 expression in representative regions of in situ (top) and invasive components (bottom) of IDC of the indicated molecular subtypes stained for ARF6 by IHC. LUM, hormone receptor positive (Luminal A + B); TNBC, hormone receptor negative, HER2 negative; HER2, hormone receptor negative, HER2 positive. Insets are higher magnification of boxed regions. Bars, 10 µm. (B and C) Semiquantitative analysis of cytosolic (B) and membranous ARF6 expression (C) by the H-score method comparing peritumoral breast epithelial tissue (n = 324), in situ (n = 131), and invasive (n = 426) components of IDCs. Comparisons were made with the Kruskal-Wallis test. **, P < 0.01; ***, P < 0.001.