Table 1. Examples of changes observed in the differentiation proteome.
| TriTrypDB ID | Description | Log2 T3C/T3N protein | Log2 T3C/T3N phosphorylationa | Classification |
|---|---|---|---|---|
| Tb927.8.1640 | MSP-B, major surface protease | +3.67 | — | Surface |
| Tb927.7.6850 | TS, trans-sialidase | +1.68 | — | Surface |
| Tb927.10.11220 | PSSA-2, procyclic form surface protein | +1.45 | — | Surface |
| Tb927.1.2100 | Calpain-like cysteine peptidase | +0.36 | S81 +4.25; S366 +3.23; T365 +2.72; S95 +2.64 | Surface |
| Tb927.11.17870 | VSG, variant surface glycoprotein | −1.75 | — | Surface |
| Tb927.5.370 | ISG75, 75-kD invariant surface glycoprotein | −2.09 | — | Surface |
| Tb927.10.8530 | THT2A, glucose transporter | +3.05 | T526 +2.83 | Metabolism |
| Tb927.10.15410 | gMDH, glycosomal malate dehydrogenase | +2.43 | — | Metabolism |
| Tb927.10.6950 | Sterol 24-C-methyltransferase | +2.12 | — | Metabolism |
| Tb927.1.710 | PGKB, phosphoglycerate kinase B | −3.58 | — | Metabolism |
| Tb927.1.2600 | PUF9, pumilio RNA binding protein | −1.98 | Cell cycle | |
| Tb927.11.11770 | eIF4e, eukaryotic translation initiation factor 4e | +0.20 | T159 +2.89 | Cell cycle |
| Tb927.11.1820 | eIF2b, eukaryotic translation initiation factor 2b | +0.19 | S126 +2.57; T127 +2.57 | Cell cycle |
| Tb927.9.6100 | PIP39, PTP1-interacting protein | +2.50 | — | Signaling |
| Tb927.7.5940 | PAD2, protein associated with differentiation 2 | +0.05 | T577 -4.46; T587 −3.65 | Signaling |
| Tb927.7.5990 | PAD7, protein associated with differentiation 7 | −0.15 | T584 +7.01; S580 +3.44; S582 +2.71 | Signaling |
| Tb927.6.3490 | ZFP1, zinc finger protein 1 | — | S18 +2.81; S16 +2.56 | Signaling |
a
For proteins with multiple phosphorylation sites, only those with the largest changes are given; see Table S3 for full details. Missing values were either not observed or not quantified.