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. 2015 Oct 26;211(2):233–242. doi: 10.1083/jcb.201409035

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© 2015 Bohr et al.

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Figure 1. — MAD-1, MAD-2, and BUB-3 are required for the synapsis checkpoint. (A) Meiotic checkpoints in C. elegans. (B) Mutation of mad-1, mad-2, or bub-3, but not mad-3, reduces germline apoptosis in meDf2/+. (C) Mutation of mad-1 or bub-3 reduces germline apoptosis in syp-1 and spo-11;syp-1 mutants, whereas mutation of mad-3 reduces apoptosis in syp-1 but not in spo-11;syp-1 mutants. (D) Mutation of mad-2 reduces germline apoptosis in syp-1 and cep-1;syp-1 mutants. Error bars represent ±SEM. *, P < 0.01; **, P < 0.0001 in all graphs.