Table 2.
Differentially expressed genes (5 % FDR) in severe vs mild disease as characterized both by a decline in % predicted DLCO and FVC
| Transcript ID | Gene symbol | p-value (Severe vs Mild DLCO) | Severe/Mild Fold Change (DLCO) | p-value (Severe vs Mild FVC) | Severe/Mild Fold Change (FVC) |
|---|---|---|---|---|---|
| 7922229 | SELE | 9.4E-05 | 2.87 | 2.9E-05 | 2.80 |
| 7921821 | ADAMTS4 | 5.0E-05 | 2.22 | 2.8E-06 | 2.41 |
| 8146957 | PI15 | 1.9E-05 | 2.04 | 1.7E-06 | 2.16 |
| 8043981 | IL1R2 | 0.00035 | 1.86 | 2.5E-05 | 2.00 |
| 7976496 | SERPINA3 | 9.5E-06 | 1.81 | 3.3E-05 | 1.76 |
| 8088560 | ADAMTS9 | 1.4E-05 | 1.84 | 8.5E-05 | 1.75 |
| 8162276 | NFIL3 | 0.00011 | 1.59 | 6.9E-06 | 1.63 |
| 7974851 | HIF1A | 6.8E-07 | 1.52 | 2.7E-07 | 1.57 |
| 8145122 | SLC39A14 | 0.00012 | 1.51 | 1.9E-05 | 1.51 |
| 8113220 | ELL2 | 8.2E-06 | 1.52 | 2.6E-05 | 1.51 |
| 8106743 | VCAN | 8.3E-05 | 1.48 | 0.00014 | 1.49 |
| 7921344 | ELL2 | 1.6E-05 | 1.56 | 3.0E-05 | 1.49 |
| 7902227 | GADD45A | 2.6E-05 | 1.33 | 6.4E-08 | 1.48 |
| 8059376 | SERPINE2 | 0.00031 | 1.57 | 0.00013 | 1.45 |
| 8043909 | NPAS2 | 5.2E-05 | 1.56 | 0.00067 | 1.45 |
| 7897449 | SPSB1 | 0.00011 | 1.36 | 4.3E-06 | 1.44 |
| 8044391 | MERTK | 0.00015 | 1.46 | 1.5E-05 | 1.43 |
| 8168749 | SRPX2 | 1.9E-06 | 1.57 | 3.0E-05 | 1.43 |
| 8156043 | PSAT1 | 0.00017 | 1.40 | 9.0E-06 | 1.43 |
| 8115814 | SH3PXD2B | 3.0E-05 | 1.47 | 3.0E-05 | 1.42 |
| 8106098 | MAP1B | 3.4E-05 | 1.48 | 0.00019 | 1.42 |
| 8157216 | UGCG | 3.8E-05 | 1.39 | 5.3E-06 | 1.41 |
| 8099685 | LGI2 | 0.00032 | 1.45 | 0.00018 | 1.40 |
| 8007931 | ITGB3 | 4.4E-05 | 1.37 | 5.2E-05 | 1.40 |
| 7986446 | ALDH1A3 | 3.1E-05 | 1.49 | 0.0020 | 1.37 |
| 8105040 | OSMR | 0.00012 | 1.33 | 3.00E-05 | 1.35 |
| 8043995 | IL1R1 | 3.4E-05 | 1.34 | 3.8E-05 | 1.35 |
| 7922610 | ABL2 | 0.00034 | 1.39 | 3.8E-05 | 1.33 |
| 7915787 | PIK3R3 | 2.9E-05 | 1.26 | 4.9E-05 | 1.33 |
| 8006123 | CPD | 0.00017 | 1.24 | 3.2E-05 | 1.27 |
| 8066939 | B4GALT5 | 0.00026 | 1.25 | 3.2E-05 | 1.27 |
| 8133155 | TPST1 | 0.00021 | 1.32 | 1.1E-05 | 1.25 |
| 8041168 | SNORD53 | 0.00019 | 1.30 | 0.0018 | 1.25 |
| 8102482 | SEC24D | 1.0E-05 | 1.31 | 5.5E-05 | 1.24 |
| 8041149 | WDR43 | 0.00010 | 1.29 | 0.00079 | 1.24 |
| 7985934 | SEMA4B | 0.00012 | 1.21 | 8.8E-05 | 1.23 |
| 8076515 | ARFGAP3 | 0.00013 | 1.26 | 0.00035 | 1.21 |
| 8117128 | E2F3 | 3.5E-06 | 1.27 | 0.00022 | 1.20 |
| 7966839 | VSIG10 | 0.00021 | −1.17 | 0.0026 | −1.15 |
| 8109086 | ADRB2 | 0.00015 | −1.24 | 0.0013 | −1.17 |
| 8035201 | CPAMD8 | 5.5E-05 | −1.30 | 0.0010 | −1.22 |
| 8041206 | LBH | 0.00036 | −1.33 | 0.0015 | −1.26 |
| 7940530 | C11orf9 | 3.2E-05 | −1.24 | 0.0019 | −1.27 |
| 8149885 | ADRA1A | 1.7E-05 | −1.33 | 4.1E-05 | −1.27 |
| 8082465 | CCDC48 | 9.8E-05 | −1.28 | 8.1E-06 | −1.28 |
| 8038117 | DBP | 0.00019 | −1.35 | 0.00016 | −1.31 |
| 8057677 | SLC40A1 | 0.00038 | −1.41 | 0.0023 | −1.32 |
| 7968650 | C13orf36 | 7.1E-06 | −1.38 | 0.00019 | −1.34 |
| 8089467 | ZBED2 | 3.5E-05 | −1.45 | 0.00021 | −1.45 |
| 8171248 | KAL1 | 5.3E-05 | −1.67 | 0.00077 | −1.50 |
| 8155734 | FAM189A2 | 2.0E-05 | −1.56 | 4.0E-05 | −1.54 |
| 8156569 | MIR23B | 0.00024 | −1.71 | 3.0E-06 | −1.66 |
| 8179967 | AGER | 6.22E-05 | −1.81 | 0.0023 | −1.74 |
| 8125341 | AGER | 7.5E-05 | −1.42 | 0.0026 | −1.77 |
| 8178771 | AGER | 7.1E-05 | −1.67 | 0.0025 | −1.78 |
| 8109383 | GRIA1 | 4.9E-06 | −1.86 | 3.4E-05 | −1.81 |
| 8171427 | FIGF | 0.00028 | −2.07 | 0.0011 | −1.90 |
| 7933855 | RTKN2 | 0.00020 | −2.57 | 0.0016 | −2.34 |