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. 2015 Jul 17;6(21):18293–18313. doi: 10.18632/oncotarget.4715

Figure 2. Effects of AICAR and running on AMPK activation and synaptic plasticity markers in dentate gyrus (DG) and lateral entorhinal cortex (LEC).

Figure 2

A, B. AMPK phosphorylation (pAMPK) in (A) DG and (B) LEC, immunoblotting of tissue after 7 days and 14 days of treatment in control (CTR), AICAR treated (ACR) and voluntary running (RUN) mice. pAMPK is increased in (A) DG by both interventions at 14 days and (B) in the LEC only by running. C. DG BDNF levels are elevated in ACR7, RUN7 and RUN14 but not in the ACR14 group; D. No change in BDNF protein in the LEC; E–F. DG BrdU-positive cell number increases in ACR7, RUN7 and RUN14 but not ACR14 mice; G. Photomicrographs of BrdU-positive cells after 7 (left column) and 14 (right column) days. Sections derived from CTR7 and CTR14 groups (first row), ACR7 and ACR14 (second row) and RUN7 and RUN14 (third row) mice. Scale bar represents 250 μm in overview images and 25 μm in the high magnification inserts. (*p < 0.05; compared to CTR; **p < 0.05 compared to CTR and ACR). Error bars denote S.E.M.