Table 4a. Univariate and multivariate analysis with OS.
| Variates | Univariate analysis (OS) | Multivariate analysis (OS) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| ENI | 2.484 | 1.496–4.126 | 0.0004 | 2.988 | 1.396–6.399 | 0.0048 |
| LDH | 2.746 | 1.661–4.541 | < 0.0001 | 1.502 | 0.777–2.903 | 0.2262 |
| Stage | 1.558 | 0.950–2.553 | 0.0787 | 0.674 | 0.325–1.399 | 0.2900 |
| IPI | 2.801 | 1.714–4.576 | < 0.0001 | 0.809 | 0.343–1.908 | 0.6279 |
| ECOG PS ≥ 2 | 2.552 | 1.486–4.383 | 0.0007 | 1.603 | 0.833–3.085 | 0.1580 |
| MYC+ | 5.515 | 3.339–9.108 | < 0.0001 | 3.127 | 1.649–5.929 | 0.0005 |
| BCL2+ | 2.086 | 1.243–3.500 | 0.0054 | 0.934 | 0.465–1.875 | 0.8471 |
| BCL6+ | 0.665 | 0.415–1.066 | 0.0905 | 0.792 | 0.434–1.443 | 0.4458 |
| Non-GCB | 0.640 | 0.387–1.059 | 0.0825 | 0.710 | 0.335–1.502 | 0.3705 |
| MYC-R+ | 4.715 | 2.873–7.739 | < 0.0001 | 7.527 | 2.358–24.031 | 0.0007 |
| DHL | 1.724 | 1.116–2.563 | 0.0070 | 1.595 | 1.005–2.534 | 0.0478 |
| MYC CNA+ | 5.344 | 2.790–10.234 | < 0.0001 | 3.058 | 1.227–7.620 | 0.0164 |
| BCL2 CNA+ | 3.808 | 2.373–6.111 | < 0.0001 | 2.619 | 1.417–4.840 | 0.0002 |
| MC+BC+ | 3.504 | 2.460–4.991 | < 0.0001 | 2.414 | 1.510–3.860 | 0.0021 |
Abbreviations: OS: overall survival; HR: hazard; ENI: extranodal involvement; LDH: serum lactate dehydrogenase; IPI: International Prognostic Index; ECOG PS: performance status of Eastern Cooperative Oncology Group; +: positive; GCB: germinal-center B-cell; R: rearrangement; DHL: double hit lymphoma; CNA: copy number aberration; MC+BC+: double CNA of MYC and BCL2.