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A hypothetical cascade pathway of the suppression of tumor cell invasion and proliferation by AGPAT9. AGPAT9 could significantly inhibit the V-ATPase activity and extracellular hydrogen ion concentration, and in turn the activation of secreted MMP-2/MMP-9, which ultimately suppressed tumor's invasion. AGPAT9 inhibited breast cancer proliferation through, at least in part, suppressing the V-ATPase activity and Wnt/β-catenin pathway.
