Table 4. Univariate and multivariate analysis of prognostic variables by Cox regression analysis.

Clinicopathological factors	Univariate analysis		Multivariate analysis
	RR (95% CI)	P-value	RR (95% CI)	P-value
TNM stage (I/II/III)	1.122(0.54-2.34)	0.001*	34.1 (8.51-136.7)	0.001*
Edmondson grade (I/II/III)	1.198(0.98-4.04)	0.02*	2.64 (1.39-5.02)	0.003*
miR-451 expression (low / high)	1.52 (1.08-2.12)	0.016*	2.09 (1.20-3.63)	0.009*

RR: relative ratio; 95% CI: 95% confidence interval.