Table 3. Univariate and Multivariate analysis of clinical parameters in relation to progression-free survival.

	Univariate		Multivariate
Variables	HR (95%CI)	P	HR (95%CI)	P
miR-26a expression	3.115 (1.714–4.211)	0.008*	4.226 (1.415–10.321)	< 0.001*
Age at diagnosis	1.724 (0.566–2.341)	0.731	1. 578 (0.628–1.874)	0.416
Gender	2.154 (0.763–3.215)	0.329	1.984 (0.458–2.409)	0.471
Clinical stage at diagnosis	4.252 (1.472–6.179)	0.004*	3.241 (1.762–5.745)	< 0.001*
Invasion depth	2.112 (0.751–3.14)	0.195	2.154 (0.793–2.853)	0.217
Lymph vessel infiltration	2.791 (1.415–4.117)	0.042*	2.117 (1.317–4.561)	0.017*
Distant metastasis	5.104 (1.998–10.179)	< 0.001*	4.219 (2.326–7.619)	< 0.001*
Differentiation	3.146 (1.342–5.145)	0.042*	2.754 (1.532–4.156)	0.014*

CI: confidence interval; HR: hazard ratio;

^*Significant relation of clinical parameters with progression-free survival