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. 2015 Jun 22;6(21):18641–18652. doi: 10.18632/oncotarget.4080

Figure 1. Model of the p53 DNA binding domain structural groups.

Figure 1

Three-dimensional ribbon diagram of the p53 DNA BD (White) and wire diagram of the DNA double helix backbone. Red: residues that interact directly with the DNA major groove. Blue: R248 residue that interacts directly with the DNA minor groove. Yellow: SLH motif stabilizing residues that support the tertiary structure opposite of the DNA major groove binding interface. Green: Zinc ion and zinc ion coordinating residues that stabilize part of the DNA binding interface.