Table 3. Characteristics of optimally cytoreduced DNA binding domain TP53 missense mutation cases by reduced structural groups.
| Major groove | Minor groove | Other MM | SLH stabilizer | Wild-type | Zinc binder | p-value | |
|---|---|---|---|---|---|---|---|
| Age | 58.6 | 61.1 | 59.3 | 55.1 | 65.5 | 49.1 | 0.111a |
| Stage | 0.356a | ||||||
| IIA/B/C | 1 | 0 | 3 | 0 | 0 | 0 | |
| IIIA/B | 2 | 2 | 4 | 1 | 1 | 0 | |
| IIIC | 15 | 7 | 63 | 5 | 10 | 5 | |
| IV | 2 | 4 | 11 | 3 | 3 | 3 | |
| Grade | 0.209a | ||||||
| G2 | 1 | 0 | 8 | 0 | 3 | 2 | |
| G3 | 18 | 13 | 73 | 7 | 10 | 6 | |
| Platinum status | 0.114b | ||||||
| Sensitive | 10 | 6 | 40 | 4 | 4 | 4 | |
| Resistant | 5 | 4 | 13 | 3 | 7 | 0 | |
| TP53 copy number alteration | 0.820a | ||||||
| Gain | 1 | 2 | 8 | 0 | NA | 1 | |
| Heterozygous loss | 15 | 9 | 59 | 6 | NA | 7 | |
| Diploid | 4 | 2 | 14 | 3 | NA | 0 | |
| Total tumor mutations | 46.5 | 38.0 | 49.8 | 41.0 | 29.0 | 35.0 | 0.802a |
| BRCA1/2 germline mutation | 6/29 | 3/16 | 18/118 | 1/9 | 3/13 | 2/16 | 0.914b |
All reported values are exact counts or median values.
a
Kruskal-Wallis test
b
Fisher's Exact test