Table 3.
Functional enrichment analysis of top ranked SNPs
| Different riched methods | Related pathways of riched functional analysis | P value | Related genes of riched functional analysis |
|---|---|---|---|
| Wikipathways pathway | Inflammatory Response Pathway | 0.0013 | IL4R, LAMC2, LAMA5, COL1A1 |
| Focal Adhesion | 0.0029 | SPP1, COL1A1, COL5A1, EGF, TNXB, ROCK1, LAMC2, PIK3CG, LAMA5 | |
| TGF Beta Signaling Pathway | 0.0097 | EP300, SPP1, JAK1, EGF | |
| KEGG pathway | ECM-receptor interaction | 0.0004 | GP9, SPP1, LAMA5, LAMC2, COL1A1, COL5A1, TNXB |
| Focal adhesion | 0.0015 | SPP1, FLT4, COL1A1, COL5A1, EGF, TNXB, ROCK1, LAMC2, LAMA5, PIK3CG | |
| Phenylalanine metabolism | 0.0044 | IL4I1, AOC2, ALDH3B2 | |
| Jak-STAT signaling pathway | 0.0063 | IFNE, EP300, IL4R, IL11RA, JAK1, PIK3CG, CBLB | |
| Hematopoietic cell lineage | 0.0085 | CD1E, GP9, IL4R, IL11RA, CD22 | |
| Inositol phosphate metabolism | 0.0111 | PLCB4, PIK3C2B, PIK3CG, PIK3C2A | |
| Pathway Commons pathway | Intrinsic Pathway | 0.0015 | GP9, C1QBP, A2M, F13A1 |
| Formation of Fibrin Clot (Clotting Cascade)- | 0.0021 | GP9, C1QBP, A2M, F13A1 | |
| Hemostasis | 0.0054 | TTN, OL1A1, A2M, EGF, F13A1, GP9, MAG, C1QBP | |
| Platelet Activation | 0.0054 | GP9, COL1A1, A2M, EGF, F13A1 | |
| Exocytosis of Alpha granule | 0.0050 | GP9, A2M, EGF, F13A1 | |
| Platelet degranulation | 0.0059 | GP9, A2M, EGF, F13A1 | |
| Terminal pathway of complement | 0.0037 | C8G, C7 | |
| vWF interaction with collagen | 0.0037 | GP9, COL1A1 |