Table 1.

Pivotal toxicology studies conducted with the GNP drug product

Study type	Species/N/Gender	Test articles and dosage
28-day sub-chronic toxicology	Rat/71M/71F	Saline, placebo liquid, GNP ingredients in solution at 0.1 and 0.2 mg/rat/day for 28 days
28-day sub-chronic toxicology	Dog/16M/16F	Saline, placebo powder, GNP at 2 and 4 mg/dog/day for 28 days
Acute toxicology	Rat/16M/16F	Air placebo control, GNP at 0.5 mg intra-tracheally
Acute toxicology	Rabbit	30-mg drug product administered directly in eye

M male, F female