Table 2.

Summary toxicokinetic parameters of glucagon in rats (gender combined)

Day	Group	Dose level of glucagon (mg/day)	Mean (± SE)
			AUC0–t (pg min/mL)	AUC0–90 (pg min/mL)	Cmax (pg/mL)	tmax (min)	RA
1	Low dose	0.1	8095 ± 3266	8095 ± 3266	390 ± 240	10.0	NC
	High dose	0.2	172,893 ± 72,774	172,893 ± 72,774	9961 ± 6443	10.0	NC
28	Low dose	0.1	43,036 ± 21,047	43,036 ± 21,047	988 ± 851	60.0	5.31
	High dose	0.2	60,073 ± 20,639	60,073 ± 20,639	2109 ± 1464	20.0	0.347

NC not calculated