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. 2015 Oct 26;16:29. doi: 10.1186/s40360-015-0026-9

Table 3.

Summary of hematology, coagulation, clinical chemistry, and urinalysis data in dogs, Day 29 relative to start datea

Parameter Group 1: Placebo control Group 2: Saline control Group 3: Low dose Group 4: High dose
Hematology
Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 9) Male (N = 8) Female (N = 9)
 Red blood cells (1012/L) 8.62 (0.433) 8.08 (0.378) 8.52 (0.298) 8.14 (0.236) 8.59 (0.441) 8.19 (0.393) 8.49 (0.379) 8.26 (0.267)
 Hemoglobin (g/L) 149 (6.8) 142 (6.2) 148 (5.7) 144 (3.1) 149 (6.7) 144 (6.4) 147 (7.7) 144 (3.7)
 Hematocrit (L/L) 0.47 (0.019) 0.44 (0.015) 0.47 (0.019) 0.45 (0.010) 0.47 (0.023) 0.44 (0.021) 0.47 (0.027) 0.45 (0.011)
 Mean corpuscular volume (fL) 55.1 (1.69) 54.5 (1.45) 55.4 (1.16) 55.1 (1.05) 55.0 (1.21) 54.3 (1.22) 55.1 (2.07) 54.7 (1.58)
 Mean corpuscular hemoglobin (pg) 17.3 (0.35) 17.6 (0.52) 17.4 (0.25) 17.7 (0.41) 17.3 (0.37) 17.5 (0.42) 17.3 (0.71) 17.4 (0.40)
 Mean corpuscular hemoglobin concentration (g/L) 314 (4.6) 323 (7.1) 314 (3.0) 321 (4.1) 315 (3.9) 323 (5.0) 313 (6.5) 319 (6.3)
 Platelets (109/L) 926 (148.3) 941 (105.1) 966 (186.9) 887 (123.7) 895 (169.0) 901 (136.8) 864 (122.1) 821 (194.5)
 % Reticulocytes (%) 1.79 (0.652) 1.66 (0.517) 1.95 (0.477) 1.57 (0.381) 2.01 (0.377) 1.76 (0.463) 1.83 (0.320) 1.66 (0.457)
 Reticulocytes (1012/L) 0.152 (0.0491) 0.133 (0.0379) 0.165 (0.0364) 0.128 (0.0318) 0.171 (0.0219) 0.143 (0.0363) 0.155 (0.0257) 0.136 (0.0363)
 White blood cells (109/L) 8.44 (1.498) 5.56 (1.867) 9.08 (1.476) 6.92 (1.547) 9.41 (2.417) 6.28 (2.144) 8.90 (2.046) 5.00 (1.472)
 Neutrophils (109/L) 0.74 (0.188) 0.40 (0.165) 0.82 (0.299) 0.39 (0.109) 0.85 (0.263) 0.47 (0.114) 0.82 (0.264) 0.43 (0.140)
 Lymphocytes (109/L) 7.40 (1.349) 4.94 (1.803) 7.89 (1.294) 6.21 (1.362) 8.20 (2.338) 5.59 (1.997) 7.73 (2.029) 4.37 (1.432)
 Monocytes (109/L) 0.13 (0.049) 0.11 (0.060) 0.19 (0.044) 0.16 (0.070) 0.18 (0.058) 0.10 (0.027) 0.19 (0.080) 0.09 (0.039)
 Eosinophils (109/L) 0.10 (0.026) 0.07 (0.023) 0.11 (0.040) 0.09 (0.034) 0.10 (0.033) 0.08 (0.017) 0.09 (0.027) 0.07 (0.033)
 Basophils (109/L) 0.03 (0.010) 0.02 (0.007) 0.03 (0.010) 0.02 (0.007) 0.03 (0.019) 0.02 (0.011) 0.03 (0.012) 0.02 (0.010)
 Leucocytes (109/L) 0.04 (0.012) 0.03 (0.015) 0.04 (0.017) 0.05 (0.039) 0.05 (0.033) 0.03 (0.027) 0.05 (0.022) 0.02 (0.011)
Coagulation
Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 9) Male (N = 8) Female (N = 9)
 Prothrombin time (Sec) 13.5 (0.53) 13.3 (0.54) 13.4 (0.35) 13.7 (0.53) 13.3 (0.34) 13.5 (0.34) 13.6 (0.41) 13.7 (0.39)
 Activated partial thromboplastin time (Sec) 17.1 (1.28) 15.5 (2.78) (N = 9) 16.5 (1.03) 16.6 (1.25) 16.8 (1.68) 16.2 (0.97) 16.1 (0.68) 16.2 (1.05)
Clinical chemistry
Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 10)
 Alanine transaminase (U/L) 27 (4.5) 29 (8.7) 30 (5.4) 30 (7.4) 31 (8.7) 34 (14.3) 28 (7.1) 31 (9.9)
 Aspartate aminotransferase (U/L) 138 (35.4) 114 (18.1) 124 (30.3) 120 (25.5) 148 (24.0) 135 (44.6) 130 (26.9) 120 (49.3)
 Alkaline phosphatase (U/L) 140 (25.9) 70 (17.9) 139 (19.9) 70 (12.2) 135 (28.3) 65 (15.5) 127 (30.3) 55 (12.9)
 Total bilirubin (μmolL) 2.1 (0.58) (N = 3) 1.9 (0.14) (N = 2) 2.0 (0.21) (N = 2) 1.9 (0.00) (N = 2) 1.9 (−) (N = 1) 2.1 (0.21) (N = 3) 2.2 (−) (N = 1) 2.2 (0.29) (N = 4)
 Cholesterol (mmol/L) 1.80 (0.561) 1.85 (0.432) 1.67 (0.311) 1.84 (0.354) 1.49 (0.416) 2.0 (0.453) 1.76 (0.288) 1.75 (0.313)
 Triglycerides (mmol/L) 0.57 (0.252) 0.28 (0.050) 0.57 (0.136) 0.36 (0.113) 0.55 (0.229) 0.38 (0.108) 0.57 (0.203) 0.34 (0.088)
 Glucose (mmol/L) 7.5 (1.06) 6.9 (1.75) 7.1 (0.85) 8.5 (1.85) 7.4 (0.92) 8.1 (2.19) 8.4 (2.41) 9.1 (1.37)
 Total protein (g/L) 59 (4.0) 61 (5.8) 59 (2.2) 62 (2.9) 59 (3.2) 64 (3.5) 61 (2.0) 65 (4.5)
 Albumin (g/L) 39 (2.3) 44 (4.1) 39 (0.9) 43 (1.8) 38 (2.6) 45 (2.5) 39 (1.7) 48 (5.0)
 Globulin (g/L) 20 (2.4) 17 (2.4) 21 (1.5) 19 (2.1) 21 (2.1) 19 (1.5) 22 (2.4) 18 (2.0)
 Albumin/Globulin ratio 2.0 (0.24) 2.6 (0.30) 1.9 (0.12) 2.3 (0.26) 1.8 (0.23) 2.4 (0.17) 1.8 (0.24) 2.7 (0.53)
 Urea (mmol/L) 5.0 (0.78) 5.4 (0.87) 4.6 (0.67) 5.2 (0.69) 5.1 (0.87) 5.8 (1.01) 5.6 (0.90) 5.1 (0.40)
 Creatinine (μmolL) 22 (3.3) 28 (2.5) 21 (3.0) 28 (5.1) 25 (2.9) 28 (5.5) 26 (2.0) 29 (3.0)
 Calcium (mmol/L) 2.55 (0.116) 2.52 (0.064) 2.60 (0.044) 2.57 (0.069) 2.59 (0.080) 2.63 (0.093) 2.60 (0.077) 2.68 (0.075)
 Phosphate (mmol/L) 2.45 (0.162) 2.07 (0.126) 2.53 (0.145) 2.06 (0.249) 2.54 (0.174) 2.10 (0.224) 2.54 (0.269) 2.06 (0.213)
 Sodium (mmol/L) 143 (1.1) 143 (1.7) 144 (1.5) 142 (1.8) 146 (1.0) 145 (2.1) 147 (1.4) 146 (1.4)
 Potassium (mmol/L) 5.1 (0.20) 4.7 (0.39) 5.0 (0.31) 5.1 (0.35) 5.2 (0.32) 5.0 (0.47) 5.3 (0.60) 4.8 (0.26)
 Chloride (mmol/L) 102 (1.9) 105 (1.9) 102 (1.6) 104 (2.3) 104 (0.9) 105 (1.6) 104 (1.7) 105 (1.3)
 Urinalysis
Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 9)
 Volume (mL) 7 (3.5) 7 (5.6) 9 (2.9) 5 (2.6) 7 (5.4) 5 (2.4) 10 (3.8) 9 (6.7)
 Specific gravity 1.030 (0.0090) 1.028 (0.0138) 1.024 (0.0077) 1.027 (0.0083) 1.027 (0.0112) 1.026 (0.0079) 1.024 (0.0068) 1.021 (0.0156)

aAll data are presented as mean (standard deviation)