Claudiani 1995.

Clinical features and settings	Stuy period: beginning of 1985 to the middle of 1993. Patient population: 97 patients with suspected or histologically proven neural crest tumours of which 46 with a ¹²³I‐MIBG scan. Consecutive series: n.r. Diagnostic work‐up: US, X‐ray, CT or MRI, or a combination of these tests, within a short period before or after ¹²³I‐MIBG scintigraphy. Time spans symptoms‐index test, symptoms‐reference standard and index test‐reference standard: n.r. Treatment between index test‐reference standard: n.r.
Participants	Included patients: 46 of 97 children with suspected or histologically proven neural crest tumours had a ¹²³I‐MIBG scan. Median age: n.r. for these 46 included patients:for all 97 patients the range : 6 months to 12 years. Sex distribution:n.r. for these 46 included patients; for all 97 patients:50 boys (52%), 47 girls (48%). INSS stage: n.r. According to the Italian Association of Paediatric Hematology and Oncology (AIEOP) staging criteria and on the basis of the biopsy results staging for all 97 patients was: 3 group 1 neuroblastoma, 12 group 2 neuroblastoma, 25 group 3 neuroblastoma, 45 group 4 neuroblastoma, 2 group 5 neuroblastoma, 5 group 2 to 4 ganglioneuroblastoma and 5 ganglioneuromas.
Study design	Cohort study with patients from the HR‐NBL1/SIOPEN trial. N.r. whether the study was retrospective or prospective.
Target condition and reference standard(s)	Target condition: newly diagnosed neuroblastoma. Reference standard: histopathology (tumour biopsy with cytological and histological examination).
Index and comparator tests	Index test: ¹²³I‐MIBG and ¹³¹I‐MIBG scintigraphy. Radiofarmacon: ¹²³I‐MIBG. Dose: 1.85 MBq/kg. Collimator: low‐energy, all‐purpose. Matrix: not reported. Acquisition protocol: n.r. Acquisition time: 24 hours after injection. Acquisition duration: n.r. Interfering medication: not reported. Thyroid prophylaxis: not reported. Positive test result: n.r Number and expertise of observers: n.r. Interobserver concordance: n.r.
Follow‐up	n.r.
Notes	Results n.r. for ¹²³I‐MIBG scans separately from the ¹³¹I‐MIBG scans. Contact information of the authors: not available.