Hadj‐Djilani 1995.

Clinical features and settings	Study period: n.r. Patient population: 27 patients with neuroblastoma. Consecutive series: n.r. Diagnostic work‐up: physical examinations, urinary catecholamines, bone marrow biopsies and smears and radiological studies. Time span between ¹²³I‐MIBG scintigraphy and bone marrow biopsy: two to 15 days. Time spans between symptoms and index test, between symptoms and reference standard and between index test and reference standard: n.r. Treatment between index test and reference standard: n.r.
Participants	Included patients: 24 children with neuroblastoma and a ¹²³I‐MIBG scan at first diagnosis. Median age: n.r. for these 24 included patients; for all 27 patients the mean age: 3.5 years (range ten days to 24 years). Sex distribution: n.r. for these 24 included patients; for all 27 patients: 19 boys (70%), 8 girls (30%). INSS stage: n.r. for these 24 included patients; for all 27 patients: 2 stage 1, 6 stage 2, 7 stage 3, 9 stage 4 and 3 stage 4.
Study design	Retrospective cohort study.
Target condition and reference standard(s)	Target condition: newly diagnosed neuroblastoma. Reference standard of primary tumour: histopathology. Reference standard of metastases: bone marrow biopsy or aspiration.
Index and comparator tests	Index test: ¹²³I‐MIBG scintigraphy. Radiofarmacon: ¹²³I‐MIBG. Dose: 3.7 MBq/kg. Collimator: n.r. Matrix: n.r. Acquisition protocol: WB planar scans. Anterior and posterior images of the whole‐body and spot images were recorded with a dual‐head gamma camera (both heads had a 3/4 inch thick crystal, 37 photo multipliers (PM) and low‐energy all‐purpose collimators). Average acquisition counts were 300 kcounts for the head (anterior, posterior and left and right lateral views), 500 kcounts for the anterior and posterior thorax, abdomen and pelvis, and 200 kcounts for the lower extremities. In the case of insufficient count rates, a minimum acquisition time of 20 minutes was preset for the views of the trunk, and of 10 minutes for the head and lower extremities. In some cases, single‐photon emission tomography (SPET) of a given area was performed 24 hours post injection. Acquisition time: 6, 24 and 48 hours after injection. Acquisition duration: n.r. Interfering medication: n.r. Thyroid prophylaxis: lugol solution one day before and three days after ¹²³I‐MIBG injection. Positive test result: n.r. Number and expertise of observers: n.r. Interobserver concordance: n.r.
Follow‐up	n.r.
Notes	Results n.r. for children between younger than 18 years separately from two adults. Results n.r. for ¹²³I‐MIBG scans separately from ¹³¹I‐MIBG scans. Contact information of the authors: not available.