Muller‐Gartner 1986.

Clinical features and settings	Study period: July 1984 to May 1985. Patient population: 15 patients with confirmed neuroblastoma with 21 ¹²³I‐MIBG and ¹³¹I‐MIBG scans. Consecutive series: yes. Diagnostic work‐up: n.r. Time spans between symptoms and index test, between symptoms and reference standard and between index test and reference standard: n.r. Treatment between index test and reference standard: n.r.
Participants	Included patients: 15 children with newly diagnosed neuroblastoma with ¹²³I‐MIBG scintigraphy at diagnosis. Median age: 3 years (range 0.2 to 14 years). Sex distribution: n.r. INSS stage: 3 stage 2, 2 stage 3, 9 stage 4 and 1 stage 4S.
Study design	Cohort study. N.r. whether the study was retrospective or prospective.
Target condition and reference standard(s)	Target condition: newly diagnosed neuroblastoma. Reference standard of primary tumour: histopathology. If neuroblastoma could be excluded by US, radiological examinations, urinary catecholamines and bone marrow biopsy, a pathological ¹²³I‐MIBG uptake was deemed to be false‐positive and a physiological ¹²³I‐MIBG distribution right‐negative.
Index and comparator tests	Index test: ¹²³I‐MIBG and ¹³¹I‐MIBG scintigraphy. Radiofarmacon: ¹²³I‐ and ¹³¹I‐MIBG. Dose: 111 to 185 MBq. Collimator: n.r. Matrix: n.r. Acquisition protocol: anterior and posterior spot images of head; thorax, neck and upper arms; abdomen; upper legs and proximal tibiae; and SPECT scans. Acquisition time: 24 and 48 hours after injection. Acquisition duration: 200 kcounts for the head (lateral views); 400 to 1000 kcounts for the thorax, neck and upper arms (anterior and posterior views); 400 to 1000 kcounts for the abdomen (anterior and posterior views); 100 to 200 kcounts for the upper legs and proximal tibiae (anterior or posterior views). SPECT: n.r. Interfering medication: n.r. Thyroid prophylaxis: 200 μg Iodide one day before and three days after tracer injection. Positive test: pathological ¹²³I‐MIBG uptake. Number and expertise of observers: n.r. Interobserver concordance: n.r.
Follow‐up	n.r.
Notes	Results n.r. for ¹²³I‐MIBG scans separately from the ¹³¹I‐MIBG scans. And results n.r. for ¹²³I‐MIBG scans at first diagnosis separately from the ¹²³I‐MIBG scans during follow‐up. Contact information of the authors: not available.