Schmiegelow 1989.

Clinical features and settings	Study period: n.r. Patient population: 96 patients with confirmed neuroblastoma (n = 71) or suspected neuroblastoma (n = 25) and with ¹²³I‐ and ¹³¹I‐MIBG scans. Consecutive series: n.r. Diagnostic work‐up: urinary catecholamines, US, CT, radiological examinations, 99mTc‐MDP‐bone scan. Time spans between symptoms and index test, between symptoms and reference standard and between index test and reference standard: n.r. Treatment between index test and reference standard: n.r.
Participants	Included patients: 31 children younger than 15 years old with neuroblastoma and with a ¹²³I‐MIBG scan at first diagnosis. Median age: n.r. for these 31 included patients; for all 71 patients with a neuroblastoma: 2 years (range 0 to 15 years). Sex distribution: n.r.for these 31 included patients; for all 71 patients with a neuroblastoma: 42 boys (59%), 29 girls (41%). INSS stage: n.r. for these 31 included patients; for all 71 patients: 7 stage 1, 9 stage 2, 13 stage 3 and 42 stage 4.
Study design	Cohort study. N.r. whether the study was retrospective or prospective.
Target condition and reference standard(s)	Target condition: newly diagnosed neuroblastoma. Reference standard:histopathology (and US, CT, radiological examinations, 99mTc‐bone scan, urinary catecholamines).
Index and comparator tests	Index test: ¹²³I‐MIBG scintigraphy. Radiofarmacon: ¹²³I‐MIBG. Dose: 30 (+10*age in years) MBq in children younger than eight years and 70 to 80 MBq in two adolescents of 16 years. Collimator: n.r. Matrix: n.r. Acquisition protocol: n.r. Acquisition time: 24 hours after injection. Acquisition duration: n.r. Interfering medication: n.r. Thyroid prophylaxis: Lugol's solution, potassium iodide or perchlorate less than 24 hours before injection of ¹²³I‐MIBG. Positive test: pathological ¹²³I‐MIBG uptake. Number and expertise of observers: n.r. Interobserver concordance: n.r.
Follow‐up	n.r.; some patients were followed for approximately 44 months.
Notes	Results not reported for ¹²³I‐MIBG scans separately from ¹³¹I‐MIBG scans. We could not get contact with the authors.