Table 1.

Top 20 prescribed, produced and environmentally loaded PhACs.

Rank	Top 20 Prescribed		Top 20 Produced		Top 20 Loaded
	Compound	# of Prescriptions	Compound	Production (kg/yr)	Compound	Mass Loading (kg/yr)
1	Acetaminophen	197,921	Potassium Chloride	1.46 × 107	Metformin HCl	1.10 × 106
2	Hydrocodone Bitartrate	125,813	Acetaminophen	1.11 × 107	Polyethylene Glycol	8.73 × 105
3	Hydrochlorothiazide	114,809	Metformin HCl	4.41 × 106	Amoxicillin Trihydrate	8.24 × 105
4	Lisinopril	97,442	Ranitidine HCl	2.79 × 106	Cephalexin	7.48 × 105
5	Levothyroxine Sodium	92,389	Gabapentin	2.52 × 106	Ranitidine HCl	6.52 × 105
6	Simvastatin	82,584	Amoxicillin Trihydrate	1.74 × 106	Trimethoprim	4.39 × 105
7	Amoxicillin	71,934	Ibuprofen	1.25 × 106	Furosemide	4.02 × 105
8	Metoprolol Succinate	68,821	Cephalexin	1.20 × 106	Levothyroxine Sodium	3.03 × 105
9	Amlodypine Besylate	63,734	Methocarbamol	9.40 × 105	Fluticasone Propionate	2.36 × 105
10	Metformin HCl	58,761	Divalproex Sodium	9.18 × 105	Gabapentin	2.00 × 105
11	Ethinyl Estradiol	53,324	Polyethylene Glycol	8.90 × 105	Atenolol	1.83 × 105
12	Azithromycin	49,902	Levothyroxine Sodium	8.32 × 105	Hydrochlorothiazide	1.53 × 105
13	Albuterol Sulfate	49,587	Metoprolol Succinate	8.26 × 105	Ciprofloxacin HCl	1.46 × 105
14	Oxycodone HCl	46,685	Trimethoprim	6.88 × 105	Acetaminophen	1.38 × 105
15	Alprazolam	44,467	Furosemide	6,62 × 105	Clopidogrel Bisulfate	1.38 × 105
16	Atorvastatin Calcium	44,150	Sulfamethoxazole	6.14 × 105	Levetiracetam	1.26 × 105
17	Fluticasone Propionate	42,683	Ciprofloxacin HCl	4.57 × 105	Levofloxacin	1.00 × 105
18	Atenolol	41,139	Omeprazole	4.29 × 105	Sulfamethoxazole	9.57 × 104
19	Omeprazole	39,700	Guaifenesin	3.83 × 105	Fexofenedine HCl	8.71 × 104
20	Zolpidem Tartrate	36,980	Carisoprodol	3.54 × 105	Valacyclovir HCl	6.58 × 104