Table 2.
Top 10 individual priority scores over all toxicity endpoints and over human, mammal, and aquatic toxicity endpoints.
| All Endpoints (N=12) | Human Endpoints (N=2) | Mouse/Rat Endpoints (N=4) | Aquatic Endpoints (N=6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rank | Compound | n | Priority Score |
Compound | n | Priority Score |
Compound | n | Priority Score |
Compound | n | Priority Score |
| 1 | Levothyroxine Sodium | 12 | 1.82 | Levothyroxine Sodium | 2 | 3.13 | Fluticasone Propionate | 2 | 2.07 | Montelukast Sodium | 6 | 2.03 |
| 2 | Ranitidine HCl | 12 | 1.65 | Fluticasone Propionate | 2 | 2.46 | Ranitidine HCl | 4 | 1.95 | Clopidogrel Bisulfate | 6 | 1.77 |
| 3 | Clopidogrel Bisulfate | 9 | 1.57 | Hydrochlorothiazide | 2 | 1.57 | Furosemide | 4 | 1.78 | Levothyroxine Sodium | 6 | 1.65 |
| 4 | Fluticasone Propionate | 10 | 1.51 | Furosemide | 2 | 1.44 | Levetiracetam | 4 | 1.70 | Simvastatin | 6 | 1.61 |
| 5 | Furosemide | 12 | 1.44 | Ranitidine HCl | 2 | 1.36 | Metformin HCl | 4 | 1.65 | Ranitidine HCl | 6 | 1.55 |
| 6 | Montelukast Sodium | 9 | 1.40 | Lisinopril | 1 | 1.25 | Clopidogrel Bisulfate | 1 | 1.59 | Telmisartan | 6 | 1.51 |
| 7 | Trimethoprim | 10 | 1.30 | Rosuvastatin Calcium | 1 | 1.22 | Atenolol | 4 | 1.52 | Bupropion HCl | 6 | 1.43 |
| 8 | Atenolol | 12 | 1.27 | Ciprofloxacin HCl | 2 | 1.21 | Hydrochlorothiazide | 3 | 1.50 | Trimethoprim | 6 | 1.42 |
| 9 | Tramadol HCl | 12 | 1.26 | Trimethoprim | 1 | 1.19 | Levothyroxine Sodium | 4 | 1.43 | Nitrofuratoin | 6 | 1.37 |
| 10 | Simvastatin | 11 | 1.23 | Estrogen, conjugated | 1 | 1.17 | Triamterene | 2 | 1.42 | Tramadol HCl | 6 | 1.36 |
| 11 | Hydrochlorothiazide | 11 | 1.16 | Clonidine | 2 | 1.17 | Tramadol HCl | 4 | 1.32 | Hydroxyzine Pamoate | 6 | 1.35 |
| 12 | Acetaminophen | 12 | 1.15 | Topiramate | 2 | 1.13 | Fexofenadine HCl | 1 | 1.32 | Acetaminophen | 6 | 1.29 |
| 13 | Metformin HCl | 12 | 1.14 | Fexofenadine HCl | 2 | 1.13 | Acetaminophen | 4 | 1.30 | Amoxicillin Trihydrate | 6 | 1.28 |
| 14 | Bupropion HCl | 12 | 1.12 | Alendronate Sodium | 1 | 1.09 | Gabapentin | 4 | 1.27 | Hydroxychloroquine Sulfate | 6 | 1.28 |
| 15 | Olmesartan Medoxomil | 7 | 1.10 | Risperidone | 2 | 1.06 | Risperidone | 4 | 1.24 | Pioglitazone HCl | 6 | 1.27 |
| 16 | Sulfamethoxazole | 9 | 1.09 | Lamotrigine | 2 | 1.06 | Lamotrigine | 4 | 1.24 | Sulfamethoxazole | 6 | 1.23 |
| 17 | Pioglitazone HCl | 8 | 1.07 | Atenolol | 2 | 1.04 | Polyethylene Glycol | 1 | 1.20 | Irbesartan | 6 | 1.22 |
| 18 | Levetiracetam | 12 | 1.06 | Tadalafil | 1 | 1.02 | Citalopram HBr | 4 | 1.20 | Furosemide | 6 | 1.21 |
| 19 | Risperidone | 12 | 1.06 | Oxycodone HCl | 2 | 0.99 | Hydrocodone Bitartrate | 3 | 1.15 | Atenolol | 6 | 1.18 |
| 20 | Citalopram HBr | 12 | 1.04 | Simvastatin | 2 | 0.98 | Penicillin V Potassium | 2 | 1.12 | Trazodone HCl | 6 | 1.18 |