Table 3.

Top 10 drug classes in priority scores over all toxicity endpoints and over human, mammal, and aquatic toxicity endpoints.

Rank	All Endpoints			Human Endpoints			Mouse/Rat Endpoints			Aquatic Endpoints
	Class	n	Priority Score	Class	n	Priority Score	Class	n	Priority Score	Class	n	Priority Score
1	Antiasthmatic	1	2.27	Thyroid Hormone	1	7.19	Antiulcer	7	2.45	Antiasthmatic	1	3.51
2	Antibiotic	15	1.68	Bronchodilator	5	0.58	Antidiabetic	5	2.04	Antibiotic	15	2.71
3	Thyroid Hormone	1	1.40	Diuretic	4	−0.02	Bronchodilator	5	1.63	Antidiabetic	5	0.92
4	Antidiabetic	5	1.11	Antihypertensive	23	−0.14	Analgesic	12	1.42	Thyroid Hormone	1	0.52
5	Antiulcer	7	0.97	Antiulcer	7	−0.14	Antibiotic	15	1.06	Antihypertensive	23	0.43
6	Bronchodilator	5	0.54	Analgesic	12	−0.14	Diuretic	4	0.83	Antiulcer	7	0.35
7	Analgesic	12	0.46	Antipsychotic	4	−0.15	Antidepressant	11	0.59	Antidepressant	11	0.17
8	Antidepressant	11	0.26	Menopause Therapy	1	−0.15	Antihypertensive	23	0.16	Anticoagulant	2	0.14
9	Antihypertensive	23	0.25	Erectile Dysfunction Treatment	1	−0.15	Anticonvulsant	12	0.14	Analgesic	12	0.01
10	Diuretic	4	0.19	Antiparkinsonian	1	−0.15	Antiinfective	5	−0.07	Antihyperlipidemic	10	−0.01